Jason Bourne takes a mission to rescue his only friend in the CIA, Martin Lindros, who disappeared in Africa while tracking shipments of yellowcake uranium. Once safely back in America, Lindros persuades Bourne to help track the money trail of terrorists buying the nuclear material in Odessa.

But once there, Bourne is hampered by confusing flashbacks of unfamiliar places and events and he wonders: Is someone brainwashing him in order to throw him off the trail? Worse, is the man he saved in Africa really Martin Lindros? Now, Bourne is alone gathering evidence while trying to stay one step ahead of the terrorists who won't let anyone stand in their way of destroying the U.S.